Wellness

The Best NAD Supplements of 2025

Spotlighting top picks like Tru Niagen, ProHealth Longevity NMN Pro, and Life Extension NAD+ Cell Regenerator. It evaluates supplements based on quality, efficacy, and user needs, offering insights into NAD precursors such as NR and NMN for cellular energy, healthy aging, and overall wellness.

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Medically reviewed by:
Last updated:
December 31, 2024
12 min read

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in cellular energy production, DNA repair, and overall metabolic health. As we age, NAD+ levels naturally decline, which may affect energy, cognitive function, and longevity. NAD supplements, often derived from precursors like NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide), aim to support healthy NAD+ levels, potentially promoting vitality and healthy aging.

We evaluated top NAD supplements based on ingredient quality, purity, brand transparency, clinical research, and user feedback. Below, we share our top picks, explain our criteria, and help you decide if a NAD supplement is right for you.

Summary of recommendations

Our Top Pick
Tru Niagen
Tru Niagen

Tru Niagen is a cutting-edge supplement designed to boost cellular health by increasing NAD+ levels for enhanced energy and resilience.

Powered by nicotinamide riboside (NR), it supports healthy aging, DNA repair, and overall cellular function, making it an excellent choice for daily wellness.

Feel free to scroll directly to our picks or read on for details about how we selected these supplements.

How we evaluated the best NAD supplements

Our criteria for selecting stand-out NAD supplements included:

  • Evidence-based ingredients: We focused on brands using NAD precursors backed by clinical research, such as NR or NMN.
  • Testing and purity: Third-party testing, GMP certification, and transparent labeling were essential. We also favored products with no unnecessary fillers.
  • Brand reputation and customer trust: Established companies with strong customer feedback and a history of quality control ranked highly.
  • Value and formulation: We considered cost per serving, dosage, and additional cofactors (like resveratrol or betaine) that may enhance NAD metabolism.

Our top pick for 2025: Tru Niagen

Pros

  • ✔ Contains nicotinamide riboside (NR), one of the most researched NAD precursors
  • ✔ Backed by multiple human clinical studies and patented by ChromaDex
  • ✔ NSF Certified for Sport ensures purity and quality
  • ✔ Well-tolerated and easy to dose

Cons

  • ✖ Premium price point
  • ✖ Single-ingredient formula may not appeal to those wanting additional cofactors

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Why we chose Tru Niagen:
Tru Niagen’s NR is at the forefront of NAD research, supported by several peer-reviewed studies demonstrating its ability to boost NAD+ levels in humans. With a strong safety profile, NSF certification, and global recognition, Tru Niagen provides a trusted, straightforward approach to NAD support. While it’s not the cheapest option, the scientific backing and credibility justify the cost for many.

Pricing: Around $40-$50 per month’s supply.

Who should use Tru Niagen:
Anyone seeking a clinically backed NR supplement from a reputable brand focused solely on boosting NAD+.

Best NMN option: ProHealth Longevity NMN Pro

Pros

  • ✔ Provides pure nicotinamide mononucleotide (NMN), another well-researched NAD precursor
  • ✔ Third-party tested for purity and potency
  • ✔ Powder form allows flexible dosing
  • ✔ Long-standing company known for quality supplements

Cons

  • ✖ Powder can be less convenient than capsules
  • ✖ More expensive than some NR options

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Why we chose ProHealth Longevity NMN Pro:
NMN is gaining traction in research communities for its potential to raise NAD+ levels effectively. ProHealth Longevity has a long history in the supplement space and tests rigorously for purity. While NMN is typically pricier and less widely studied in humans than NR, NMN Pro represents a top-tier NMN product for those drawn to this precursor.

Pricing: About $60-$80 per month (depending on dosage).

Who should use ProHealth Longevity NMN Pro:
Biohackers and longevity enthusiasts who prefer NMN as their NAD precursor and value a reputable, tested source.

Best budget-friendly choice: Life Extension NAD+ Cell Regenerator

Pros

  • ✔ Uses NR (Nicotinamide Riboside) at a lower price point than some premium brands
  • ✔ Brand reputation for quality and transparency
  • ✔ Often combined with complementary nutrients in Life Extension bundles
  • ✔ Available in capsule form for easy daily dosing

Cons

  • ✖ Less NR per serving compared to more expensive counterparts
  • ✖ Fewer specialized certifications than top-tier brands

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Why we chose Life Extension NAD+ Cell Regenerator:
Life Extension is well-respected for research-driven formulations at accessible prices. Their NAD+ Cell Regenerator leverages NR to support NAD production, making it easier for those on a budget to try this class of supplements without breaking the bank. While it may not have the same robust clinical portfolio as Tru Niagen, it still provides a credible, cost-effective alternative.

Pricing: About $20-$30 for a month’s supply.

Who should use Life Extension NAD+ Cell Regenerator:
Cost-conscious consumers who still want a reliable, NR-based NAD booster from a well-known supplement company.

Best comprehensive formula with cofactors: Thorne ResveraCel

Pros

  • ✔ Combines NR with resveratrol, quercetin, and betaine (TMG) for synergistic support
  • ✔ Rigorous third-party testing and NSF Certified for Sport
  • ✔ Targets multiple longevity pathways, including sirtuins
  • ✔ Trusted, practitioner-recommended brand

Cons

  • ✖ Higher price due to multiple premium ingredients
  • ✖ Not ideal for those who only want NAD support without extras

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Why we chose Thorne ResveraCel:
Thorne’s ResveraCel is ideal for those who believe in a more holistic approach to cellular health. By pairing NR with resveratrol (a known sirtuin activator) and other supportive compounds, it aims to enhance the body’s natural anti-aging pathways. Users who want more than just NAD boosting often appreciate this multi-ingredient formula.

Pricing: Approximately $50-$60 per month.

Who should use Thorne ResveraCel:
Individuals seeking a comprehensive cellular health supplement that combines NAD precursors with antioxidants and other longevity-supporting nutrients.

Best liposomal delivery: Quicksilver Scientific NAD+ Gold

Pros

  • ✔ Liposomal NMN for enhanced absorption and bioavailability
  • ✔ Convenient liquid form
  • ✔ Company known for advanced delivery technologies
  • ✔ May offer faster, more noticeable effects due to improved uptake

Cons

  • ✖ Expensive compared to standard capsules
  • ✖ Short shelf life after opening

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Why we chose Quicksilver Scientific NAD+ Gold:
Quicksilver Scientific specializes in liposomal delivery, which can improve nutrient absorption. Their NAD+ Gold formula uses NMN in a phospholipid solution, potentially increasing cellular uptake. Though pricey, it appeals to users who are serious about maximizing bioavailability and are willing to invest in cutting-edge delivery methods.

Pricing: Around $70-$90 per month’s supply.

Who should use Quicksilver Scientific NAD+ Gold:
Early adopters, biohackers, and those who want to test whether enhanced delivery methods make a tangible difference in how they feel.

Is a NAD supplement right for you?

NAD supplements may appeal to anyone interested in supporting cellular energy, healthy aging, and metabolic function. While human research is growing, it’s still relatively new compared to other supplements. If you’re curious, consider starting with a well-researched brand and pay attention to how you feel over time.

As always, talk to a healthcare professional before starting a new supplement regimen, especially if you have underlying health conditions or take medications.

Frequently asked questions about NAD supplements

How long does it take to see results?
Some users report improved energy or mental clarity within a few weeks, while others notice subtler changes over a couple of months. Consistency is key.

Is NR better than NMN, or vice versa?
Both NR and NMN show promise. NR has more human clinical data, while NMN research is growing rapidly. Personal preference, price, and brand reputation may guide your choice.

Are NAD supplements safe?
Studies thus far suggest NR and NMN are generally safe and well-tolerated. However, long-term effects need more exploration. Start with the recommended dosage and consult a healthcare provider if unsure.

The bottom line

NAD supplements represent an exciting frontier in the pursuit of healthy aging and cellular vitality. Tru Niagen leads the pack with strong clinical backing, while ProHealth NMN Pro, Life Extension, Thorne, and Quicksilver Scientific each offer unique approaches—be it NMN, budget-friendly NR, holistic formulas, or advanced delivery.

By choosing a reputable brand and formulating realistic expectations, you can explore whether NAD supplementation supports your goals for energy, resilience, and longevity.

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