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The Best Digestive Enzyme Supplements of 2025
Featuring top picks like Enzymedica Digest Gold + PROBIOTICS, Pure Encapsulations Digestive Enzymes Ultra, and NOW Foods Super Enzymes. It provides insights into choosing the best digestive enzyme supplement for bloating, indigestion, or specific food intolerances based on your lifestyle and dietary needs.
Bloating, indigestion, and nutrient absorption issues can put a damper on your overall well-being. Digestive enzymes help break down the foods you eat into the nutrients your body needs, potentially easing digestive discomfort and improving gut health. With a wide array of enzyme blends on the market, choosing the right one can feel overwhelming.
Our team reviewed today’s leading digestive enzyme supplements based on ingredient quality, breadth of enzyme coverage, brand reputation, third-party testing, and customer satisfaction. Below, we share our top picks, explain our selection criteria, and help you decide if digestive enzymes are right for you.
Summary of recommendations
- Best overall: Enzymedica Digest Gold + PROBIOTICS
- Best broad-spectrum formula: Pure Encapsulations Digestive Enzymes Ultra
- Best budget-friendly option: NOW Foods Super Enzymes
- Best for lactose intolerance: Lactaid Fast Act
- Best plant-based formula: MaryRuth’s Ultra Digestive Food Enzymes
Enzymedica Digest Gold + PROBIOTICS combines advanced enzymes and probiotics for optimal digestive support and nutrient absorption.
Designed to break down fats, fiber, protein, and carbs, it promotes gut health and eases digestive discomfort for improved overall wellness.
Feel free to scroll directly to our picks or read on to learn more about our evaluation process.
How we evaluated the best digestive enzyme supplements
We considered several criteria when identifying top-tier digestive enzyme supplements:
- Comprehensive enzyme profiles: The best supplements include a range of enzymes—like proteases, lipases, amylases, and lactase—to help break down proteins, fats, carbohydrates, and lactose.
- Ingredient quality and purity: We looked for brands that source enzymes from quality raw materials and avoid unnecessary fillers, artificial colors, or allergens.
- Third-party testing and brand reputation: Certifications such as GMP compliance, NSF testing, or Informed Choice boost credibility. Transparent labeling and good customer feedback also mattered.
- Suitability for dietary restrictions: Plant-based formulas, gluten-free certifications, or absence of major allergens can help those with specific dietary needs.
Our top pick for 2025: Enzymedica Digest Gold + PROBIOTICS
Why we chose Enzymedica Digest Gold + PROBIOTICS:
Enzymedica’s flagship product remains a top performer due to its robust enzyme profile and added probiotics for enhanced gut health. The formula aims to reduce bloating, gas, and discomfort after meals, and many users report noticeable improvements in digestion. Its balance of quality, complexity, and reputation makes it our top pick.
Pricing: Around $40-$50 for a one-month supply.
Who should use Enzymedica Digest Gold + PROBIOTICS:
Individuals looking for a comprehensive, high-quality enzyme supplement that supports overall digestive harmony rather than targeting just one type of food.
Best broad-spectrum formula: Pure Encapsulations Digestive Enzymes Ultra
Why we chose Pure Encapsulations Digestive Enzymes Ultra:
For those who need maximum coverage, Pure Encapsulations offers a carefully designed blend of proteases, lipases, amylases, and more to help break down a wide variety of foods. With a focus on purity and testing, this brand appeals to sensitive individuals and those who want the cleanest possible supplement.
Pricing: About $50-$60 for a one-month supply.
Who should use Pure Encapsulations Digestive Enzymes Ultra:
Individuals with sensitive systems or multiple food sensitivities who value a medical-grade formula.
Best budget-friendly option: NOW Foods Super Enzymes
Why we chose NOW Foods Super Enzymes:
NOW Foods has a long-standing reputation for quality at a reasonable cost, and their Super Enzymes formula covers the basics without breaking the bank. Although it’s not vegetarian, it offers a solid entry-level solution for common digestive discomforts.
Pricing: Around $15-$20 for a one-month supply.
Who should use NOW Foods Super Enzymes:
Budget-conscious shoppers looking for a straightforward enzyme blend to ease common digestive issues.
Best for lactose intolerance: Lactaid Fast Act
Why we chose Lactaid Fast Act:
For those who experience discomfort specifically when consuming dairy, Lactaid is a household name. Its lactase enzyme helps prevent gas, bloating, and diarrhea after eating lactose-containing foods. While not a comprehensive enzyme product, it excels at its niche purpose.
Pricing: Approximately $10-$15 for a 32-count pack.
Who should use Lactaid Fast Act:
Individuals with lactose intolerance who want a simple, targeted solution to enjoy dairy again.
Best plant-based formula: MaryRuth’s Ultra Digestive Food Enzymes
Why we chose MaryRuth’s Ultra Digestive Food Enzymes:
MaryRuth’s caters to clean-eating enthusiasts who want a vegan, allergen-free enzyme supplement. Its microbial-derived enzymes effectively help break down proteins, carbs, and fats while keeping the ingredient list simple and plant-focused.
Pricing: Around $30-$40 for a one-month supply.
Who should use MaryRuth’s Ultra Digestive Food Enzymes:
Vegans, vegetarians, or anyone avoiding animal-derived ingredients who still need comprehensive digestive support.
Is a digestive enzyme supplement right for you?
Digestive enzymes can be helpful if you frequently experience bloating, gas, or discomfort after meals. They may also support people with specific food intolerances. However, if you suspect an underlying GI issue, consider consulting a healthcare professional before starting any supplement.
Remember, these products supplement a balanced diet. They work best alongside healthy eating habits, adequate hydration, stress management, and regular exercise.
Frequently asked questions about digestive enzyme supplements
When should I take them?
Most enzyme supplements work best taken right before or with a meal, helping to break down the foods you’re about to consume.
How long before I feel results?
Some people notice reduced bloating and discomfort within a few days. However, it can take a couple of weeks to determine if a particular formula is helping.
Can I combine enzymes with probiotics?
Yes. Many find that a combination of enzymes and probiotics provides comprehensive gut support. Some supplements include both, or you can take them separately.
The bottom line
Digestive enzyme supplements can help improve comfort, nutrient absorption, and overall gut health. Enzymedica Digest Gold + PROBIOTICS stands out for its comprehensive formula, while Pure Encapsulations, NOW Foods, Lactaid, and MaryRuth’s cater to specific needs—be it medical-grade purity, affordability, lactose intolerance relief, or a plant-based approach.
Choose the product that aligns best with your lifestyle, dietary restrictions, and digestive concerns. With consistency and the right fit, you might find meals more enjoyable and less troublesome.
